Analysis of Cyanide in Blood by Headspace-Isotope-Dilution-GC-MS

Journal article

Authors / Editors

Andersen, Jens

Research Areas

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Publication Details

Author list: Lobger LL, Petersen HW, Andersen J

Publisher: Taylor and Francis Group

Place: PHILADELPHIA

Publication year: 2008

Journal: Analytical Letters (0003-2719)

Journal acronym: ANAL LETT

Volume number: 41

Issue number: 14

Start page: 2564

End page: 2586

Number of pages: 23

ISSN: 0003-2719

eISSN: 1532-236X

Languages: English-Great Britain (EN-GB)

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Abstract

An uncomplicated, rapid, automated procedure for the analysis of low cyanide concentrations in whole blood is reported. The analysis was performed by headspace gas chromatography and mass spectrometry in the (1H12C14N) and m/z 29 (1H13C15N). Carryover from cyanide adsorption onto the surface of the needle was prevented by developing a new method that enabled automated flushing of the needle in between each cyanide analysis. Results were compared of ordinary calibrations and those of isotope dilutions. The total time of analysis was 18min for a single cyanide analysis.

Keywords

Blood, gas chromatography, headspace, mass spectrometry

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