Planning and analysis of cross-over trials in infertility

Journal article

Authors / Editors

Makubate, Boikanyo

Research Areas

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Publication Details

Author list: Makubate B, Senn S

Publisher: Wiley

Place: MALDEN

Publication year: 2010

Journal: Statistics in Medicine (0277-6715)

Journal acronym: STAT MED

Volume number: 29

Issue number: 30

Start page: 3203

End page: 3210

Number of pages: 8

ISSN: 0277-6715

eISSN: 1097-0258

Languages: English-Great Britain (EN-GB)

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Abstract

The use of cross-over trials in investigating treatments for infertility is discussed. A simple possible approach to analyzing such trials using the Mantel-Haenszel procedure is explained. A more flexible approach based on the normal-binomial mixture model of Ezzet and Whitehead is examined. It is shown how this may be implemented in various statistical packages by applying it to two real examples of trials in infertility. An approach that may be used to compare designs via simulation is explained briefly. It is concluded that provided that cross-over trials in infertility are regarded as parallel group trials with extra information rather than as cross-over trials with missing information, their use may be more promising than that has previously been concluded. Copyright (C) 2010 John Wiley & Sons, Ltd.

Keywords

cross-over trial, infertility, Mantel-Haenszel, missing data, parallel group trial

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