Neuronal firing and DNA dynamics in a neural network

Journal article

Authors / Editors

Tabi, Condrad

Research Areas

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Publication Details

Author list: Eteme AS, Tabi CB, Ateba JFB, Ekobena HPF, Mohamadou A, Kofane TC

Publisher: IOP Publishing

Place: BRISTOL

Publication year: 2018

Journal: Journal of Physics Communications (2399-6528)

Journal acronym: J PHYS COMMUN

Volume number: 2

Issue number: 12

Number of pages: 12

ISSN: 2399-6528

eISSN: 2399-6528

Languages: English-Great Britain (EN-GB)

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Abstract

We study the mutual effects of neuronal electrical activity and DNA dynamics in a network of electrically coupled neurons with nearest neighbors communication. For that we develop by means of the coupling function method, a mathematical DNA-neuron model that can be considered as an extension of the simplified Hodgkin-Huxley models. Numerically, we explore the biological properties of the model with emphasis on local phase transitions and synchronous neural activity. Our results suggest that firing and coherent behavior of neural network are controlled by DNA dynamics. Conversely, neuronal activity induces DNA electrochemical denaturation. As a result, we expect that the prominent DNA-neuron model would be worth in controlling gene expression and neurodegenerative diseases in the sensory thalamus.

Keywords

DNA, DNA denaturation, neural network, neuronal firing, synchronization

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