Protein-DNA Interaction: Effect of Helicity on Bubble Size

Journal article

Authors / Editors

Tabi, Condrad

Research Areas

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Publication Details

Author list: Tabi CB, Fouda HPE, Kofane TC

Publisher: American Scientific Publishers

Place: VALENCIA

Publication year: 2011

Journal acronym: J COMPUT THEOR NANOS

Volume number: 8

Issue number: 11

Start page: 2220

End page: 2226

Number of pages: 7

ISSN: 1546-1955

eISSN: 1546-1963

Languages: English-Great Britain (EN-GB)

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Abstract

We study the nonlinear dynamics of the DNA double helical chain using a DNA-protein interaction spin-like model. The presence of helicity is taken into account and the dynamical equations are reduced to the completely integrable nonlinear Schrodinger equation. Helicity is shown to bring about highly localized and extended bubbles in the model. It is argued that these bubbles can be used to explain the open-states in DNA, under the action of RNA-polymerase, within the process of transcription.

Keywords

Bubbles, DNA Dynamics, Helicity

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