A WITHIN HOST MODEL OF BLOOD STAGE MALARIA WITH TREATMENT

Journal article

Authors/Editors

Lungu, Edward

Research Areas

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Publication Details

Author list: Marijani T, Lungu E

Publisher: World Scientific Publishing

Place: SINGAPORE

Publication year: 2017

Journal: Journal of Biological Systems (0218-3390)

Journal acronym: J BIOL SYST

Volume number: 25

Issue number: 1

Start page: 1

End page: 27

Number of pages: 27

ISSN: 0218-3390

eISSN: 1793-6470

Languages: English-Great Britain (EN-GB)

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Abstract

We consider a mathematical model for malaria involving, susceptible red blood cells (RBCs), latent infected red blood cells (RBCs), active IRBCs, intracellular parasites, extracellular parasites and effector cells. We extend the model to include effect of treatment on the prognosis of malaria. One of the questions addressed in our study is: what range of the parameter, n(1), which denotes the number of intracellular parasites released from a naturally dying activated infected red blood cell can lead to malaria pathogenesis? Sensitivity analysis revealed that poor parametric estimation can lead to wrong disease prognosis, and consequently to over or under-prescription of treatment drugs. In malaria endemic areas where the parasite is developing resistance to the drugs, this can limit options of treatment drugs. We recommend that the administration of malaria treatment drugs should be done under supervision as is the case for TB to ensure complete adherence to treatment and reduce the emergence of malaria drug resistant strains. Secondly, we recommend that individuals with malaria or showing symptoms of the disease should be tested for other chronic infections which could complicate the treatment of malaria.

Keywords

Erythrocytic, Parasites, Red Blood Cell

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