CAN MALARIA PARASITE PATHOGENESIS BE PREVENTED BY TREATMENT WITH TUMOR NECROSIS FACTOR-ALPHA?

Journal article

Authors / Editors

Lungu, Edward

Research Areas

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Publication Details

Author list: Friedman A, Lungu EM

Publisher: AIMS Press

Place: SPRINGFIELD

Publication year: 2013

Journal: Mathematical Biosciences and Engineering (1547-1063)

Journal acronym: MATH BIOSCI ENG

Volume number: 10

Issue number: 3

Start page: 609

End page: 624

Number of pages: 16

ISSN: 1547-1063

eISSN: 1551-0018

Languages: English-Great Britain (EN-GB)

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Abstract

We consider a model incorporating the influence of innate and adaptive immune responses on malaria pathogenesis. By calculating the model reproduction number for a special representation of cytokine interaction, we have shown that the cytokine tumour necrosis factor-a can be administered to inhibit malaria infection. We have also found that if the cytokine F* and a generic drug of efficacy are administered as dual therapy then clearance of the parasite can be achieved even for a generic drug of low efficacy. Our study is recommending administration of dual therapy as a strategy to prevent parasites from developing resistance to malaria treatment drugs.

Keywords

adaptive immune response, Cytokines, innate immune response, Pathogenesis

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