Effects of replicative fitness on competing HIV strains

Journal article

Authors/Editors

Lungu, Edward

Research Areas

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Publication Details

Author list: Chirove F, Lungu EM

Publisher: Elsevier

Place: OXFORD

Publication year: 2013

Journal: BioSystems (0303-2647)

Journal acronym: BIOSYSTEMS

Volume number: 113

Issue number: 1

Start page: 28

End page: 36

Number of pages: 9

ISSN: 0303-2647

eISSN: 1872-8324

Languages: English-Great Britain (EN-GB)

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Abstract

We develop an n-strain model to show the effects of replicative fitness of competing viral strains exerting selective density-dependant infective pressure on each other. A two strain model is used to illustrate the results. A perturbation technique and numerical simulations were used to establish the existence and stability of steady states. More than one infected steady states governed by the replicative fitness resulted from the model exhibiting either strain replacement or co-infection. We found that the presence of two or more HIV strains could result in a disease-free state that, in general, is not globally stable. (c) 2013 Elsevier Ireland Ltd. All rights reserved.

Keywords

CD4(+) T cells, Mutant virus, Replicative fitness, Wild type virus

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