The effects of vertical transmission on the spread of hiv/aids in the presence of treatment.

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Author list: Kgosimore M, Lungu EM

Publisher: AIMS Press

Publication year: 2006

Journal: Mathematical Biosciences and Engineering (1547-1063)

Journal acronym: Math Biosci Eng

Volume number: 3

Issue number: 2

Start page: 297

End page: 312

Number of pages: 16

ISSN: 1547-1063

eISSN: 1551-0018

Languages: English-Great Britain (EN-GB)

Abstract

In this study, we develop a model that incorporates treatment of both juveniles who were infected with HIV/AIDS through vertical transmission and HIV/AIDS-infected adults. We derive conditions under which the burden of HIV/AIDS can be reduced in the population both in the absence of and in the presence of vertical transmission. We have determined the critical threshold parameter (R(*)(v)), which represents the demographic replacement of infectives through vertical transmission, below which treated infected juveniles can reach adulthood without causing an epidemic. Five countries in sub-Saharan Africa are used to illustrate our results. We have concluded that R(*)(v) is dependent on the current prevalence rate but that a significant proportion of infected juveniles receiving treatment can reach adulthood without causing an epidemic.

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