ZnO nanowire-FET for charge-based Sensing of protein biomolecules

Conference proceedings article

Authors/Editors

Ditshego, Nonofo

Research Areas

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Publication Details

Author list: Ditshego NMJ, Ghazali NAB, Ebert M, Sun K, Zeimpekis I, Ashburn P, de Planque MRR, Chong HMH

Publisher: IEEE

Place: NEW YORK

Publication year: 2015

Start page: 801

End page: 804

Number of pages: 4

eISBN: 978-1-4673-8155-0

Languages: English-Great Britain (EN-GB)

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Abstract

Top-down method was used to zinc oxide (ZnO) nanowire field effect transistor (NWFET) biosensor. The nanosensor was used to measure the electrical characteristics of lysozyme (LYSO) and bovin serum albumin (BSA) protein solutions in phosphate buffered saline (PBS). The LYSO and BSA proteins are oppossitely charged at measurement pH of 7.4. Subthreshold voltage shift of 340 mV and 700 mV due to surface charge effect on the device channel is obtained for the LYSO and BSA solution respectively. A NWFET sensitivity of 72 % is achieved for the LYSO proteins while the BSA proteins resulted in a sensitivity of 98%.

Keywords

bovine serum albumin (BSA), DEVICE, Field effect transistor, lysozyme (LYSO), nanosensor, Nanowire, phosphate buffered saline (PBS), zinc oxide

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