Synthetic protocols on 6H-benzllo[c]chromen-6-ones: a review

Journal article

Authors / Editors

Mazimba, Ofentse

Research Areas

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Publication Details

Author list: Mazimba O

Publisher: Scientific and Technical Research Council of Turkey

Place: ANKARA

Publication year: 2016

Journal acronym: TURK J CHEM

Volume number: 40

Issue number: 1

Start page: 1

End page: 27

Number of pages: 27

ISSN: 1300-0527

Languages: English-Great Britain (EN-GB)

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Abstract

6H-Benzo[c]chromen-6-ones serve as core structures of secondary metabolites and are of considerable pharmacological importance. Natural sources produce limited quantities, hence the need for synthetic procedures for 6 H-benzo[c]chromen-6-ones, which are herein reviewed. The literature describes protocols such as the Suzuki coupling reactions for the synthesis of biaryl, which then undergoes lactonization, reactions of 3-formylcoumarin (chromenones) with 1,3-bis(silylenol ethers), radical mediated cyclization of arylbenzoates, metal or base catalyzed cyclization of phenyl-2-halobenzoates and 2-halobenzyloxyphenols, and benzoic acid coupling with benzoquinone using electrophilic metal based catalyst. The efficient and simple procedures are those involving the reactions of Michael acceptor (chromenones and chalcones) with 1,3- and 1,5-dicarbonyl compounds.

Keywords

6 H-Benzo[c]chromen-6-ones, benzopyranone, biaryls, lactonization, Michael addition, Suzuki coupling

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