Effect of non-Newtonian characteristics of blood on magnetic targeting in the impermeable micro-vessel

Journal article

Authors/Editors

Shaw, Sachin

Research Areas

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Publication Details

Author list: Shaw S, Murthy PVSN, Pradhan SC

Publisher: Elsevier

Place: AMSTERDAM

Publication year: 2010

Journal: Journal of Magnetism and Magnetic Materials (0304-8853)

Journal acronym: J MAGN MAGN MATER

Volume number: 322

Issue number: 8

Start page: 1037

End page: 1043

Number of pages: 7

ISSN: 0304-8853

Languages: English-Great Britain (EN-GB)

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Abstract

In this investigation we consider to extended the work of Furlani and Furlani [15] by taking non-Newtonian fluid model for the blood in the impermeable micro-vessel. The behavior of blood is considered as the Herschel-Bulkley fluid which is more suitable for the micro-vessel of radius 50 mm. The expression for the fluidic force for the carrier particle traversing in the Herschel-Bulkley fluid is obtained first. Several factors that influence the magnetic targeting of the carrier particles in the microvasculature, such as the size of the carrier particle, the volume fraction of embedded magnetic nanoparticles, and the diameter of the micro-vessel are considered in the present problem. An algorithm is given to solve the system of coupled equations for trajectories of the carrier particle in the invasive case. The trajectories of the carrier particles are found in both invasive and noninvasive targeting systems. A comparison is make regarding the trajectories in these cases. Also, a prediction of the capture of therapeutic magnetic nanoparticle in the human microvasculature is made for different radii and volume fractions in both the invasive and noninvasive cases. (C) 2009 Elsevier B.V. All rights reserved.

Keywords

Herschel-Bulkley fluid, Magnetic drug delivery, Magnetic drug targeting, Multifunctional nanoparticle, Nanoparticles transport in microvasculature, Non-invasive drug targeting

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