Influence of the Inertia on Magnetic Drug Targeting in Microvessel-Casson Model

Journal article

Authors/Editors

Shaw, Sachin

Research Areas

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Publication Details

Author list: Sutradhar A, Murthy PVSN, Shaw S

Publisher: American Scientific Publishers

Place: VALENCIA

Publication year: 2016

Journal: Journal of Nanofluids (2169-432X)

Journal acronym: J NANOFLUIDS

Volume number: 5

Issue number: 6

Start page: 928

End page: 934

Number of pages: 7

ISSN: 2169-432X

eISSN: 2169-4338

Languages: English-Great Britain (EN-GB)

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Abstract

Magnetic drug targeting is one of the major non-invasive therapy applied to cure the malicious tumor in the circulatory system. The present investigation is on the multifunctional carrier particle based magnetic drug targeting in an impermeable microvessel of radius 200 mu m. Multifunctional carrier particle is used to carry the drug to the tumor position in which the drug carrier particle is embedded with therapeutics and biocompatible Fe3O4 nanoparticles of spherical shape. The fluid medium, blood in the microvessel, is considered as nonNewtonian Casson fluid. In this therapy, the carrier particle is injected into the microvessel upstream from the tumor located inside the body and a rare-earth cylindrical magnet is positioned in the vicinity of body surface to capture the carrier particle near the tumor area. The equilibrium of the fluidic force and magnetic force along with the buoyancy gives the trajectory equation of the carrier particle. The coupled governing equations are solved using fourth order Runge-Kutta method. A comparison is made with the existing literature which shows a good agreement. A comparison of the particle trajectory is also made with the results recently obtained for the Herschel-Bulkley fluid model. The influence of inertia along with the non-Newtonian parameter, nanoparticle volume fraction, distance between microvessel and magnet, and radius of the carrier particle are analyzed. It is observed that the tendency of the carrier particle to be capture near the tumor position increases with the introduction of inertia.

Keywords

Casson fluid, Effective Density, Impermeable Microvessel, Inertia Term, Magnetic drug targeting

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