Magnetic Drug Targeting in an Impermeable Microvessel with the Influence of Inertia of Multifunctional Carrier Particle

Journal article

Authors / Editors

Shaw, Sachin

Research Areas

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Publication Details

Author list: Sutradhar A, Murthy PVSN, Shaw S

Publisher: American Scientific Publishers

Place: VALENCIA

Publication year: 2016

Journal: Journal of Nanofluids (2169-432X)

Journal acronym: J NANOFLUIDS

Volume number: 5

Issue number: 5

Start page: 728

End page: 735

Number of pages: 8

ISSN: 2169-432X

eISSN: 2169-4338

Languages: English-Great Britain (EN-GB)

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Abstract

A mathematical model is presented to investigate noninvasive magnetic drug targeting of a multifunctional spherical carrier particle in blood in an impermeable microvessel. Herschel-Bulkley model is chosen to describe the non-Newtonian nature of blood flowing through the microvessel of radius 50 mu m. A dilute solution suspended with the carrier particle is injected into the microvessel upstream from the tumor located inside the body and a rare-earth cylindrical magnet is positioned in the vicinity of body surface to capture the carrier particle near the tumor zone. The inertia term is considered in the equation of motion of the carrier particle and it is assumed that the body force ( buoyancy) is also significant in comparison with the fluidic drag force and the external magnetic force experienced by the carrier particle. Along with the therapeutics, biocompatible Fe3O4 nanoparticles of spherical shape are assumed to be present in the carrier particle. Consequently, an effective density for the carrier particle is introduced. The numerical solution of the resulting coupled nonlinear equations of motion reveals that due to the assumption of buoyant force along with the acceleration of the carrier particle, lesser magnetization is sufficient to attract the carrier particle more efficiently near the tumor. It is also found that when the distance of the centre of the magnet from the axis of the microvessel ranges from the body surface to 2.5 cm, the carrier particle can be captured efficiently near the targeted site.

Keywords

Effective Density, Hershcel-Bulkley Fluid, Impermeable Microvessel, Inertia Term, Multifunctional Carrier Particles

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