Chemical speciation of copper(II) diaminediamide derivative of pentacycloundecane - a potential anti-inflammatory agent

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Author list: Odisitse S, Jackson GE, Govender T, Kruger HG, Singh A

Publisher: Royal Society of Chemistry

Place: CAMBRIDGE

Publication year: 2007

Journal: Dalton Transactions (1477-9226)

Journal acronym: DALTON T

Issue number: 11

Start page: 1140

End page: 1149

Number of pages: 10

ISSN: 1477-9226

eISSN: 1477-9234

Languages: English-Great Britain (EN-GB)

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Abstract

Formation constants of copper(II), zinc(II) and calcium(II) with 3,5-diaminodiamido-4-oxahexacyclododecane (cageL) has been studied by glass electrode potentiometry at 25 degrees C and an ionic strength of 0.15 mol dm(-3). Copper( II) forms more stable complexes with cageL than zinc( II) and calcium( II). Metal ion complexation promotes deprotonation and coordination of the amide nitrogens resulting in overall tetragonal coordination of Cu2+ suggested by the UV-visible electronic spectra. Speciation calculations using a blood plasma model suggest that zinc( II) and calcium( II) are good competitors of copper( II) in vivo. Bio-distribution experiments using Cu-64-labelled Cu(II)-cageL show that about 50% dose of the complex is retained in the body after 24 h.

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