In vitro and in vivo studies of the dermally absorbed Cu(II) complexes of N5O2 donor ligands - Potential anti-inflammatory drugs
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Author list: Odisitse S, Jackson GE
Publisher: Elsevier
Place: LAUSANNE
Publication year: 2009
Journal: Inorganica Chimica Acta (0020-1693)
Journal acronym: INORG CHIM ACTA
Volume number: 362
Issue number: 1
Start page: 125
End page: 135
Number of pages: 11
ISSN: 0020-1693
Languages: English-Great Britain (EN-GB)
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Abstract
Copper complexes of N,N'-di(aminoethylene)-2,6-pyridinedicarbonylamine and bis-(N,N-dimethylethyl)-2,6- pyridinedicarboxamide have been studied by glass electrode potentiometry, NMR, UV and IR spectroscopy as potential anti-inflammatory agents for the alleviation of inflammation associated with rheumatoid arthritis. The protonation and formation constants with Cu(II), Zn(II) and Ca(II), determined at 25 degrees C and an ionic strength of 0.15 mol dm (3) were used to calculate the copper plasma mobilizing index of the ligands. Spectroscopic studies suggested that metal ion complexation promotes deprotonation and coordination of the amide nitrogens resulting in overall tetragonal distorted copper complexes. Bio-distribution and dermal absorption studies showed the complexes to have relatively long biological half-lives with 50% of the injected dose remaining in the body 24 h after administration. (c) 2008 Elsevier B.V. All rights reserved.
Keywords
bio-distribution, Bio-modelling, Copper(II), potentiometry, Rheumatoid arthritis, Spectroscopy
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