Potentiometric and Blood Plasma Simulation Studies of Nickel(II) Complexes of Poly(amino)amido Pentadentate Ligands: Computer Aided Metal-Based Drug Design

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Author list: Odisitse S, Jackson GE

Publisher: Hindawi

Place: NEW YORK

Publication year: 2014

Journal: Bioinorganic Chemistry and Applications (1565-3633)

Journal acronym: BIOINORG CHEM APPL

Number of pages: 7

ISSN: 1565-3633

eISSN: 1687-479X

Languages: English-Great Britain (EN-GB)

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Abstract

The thermodynamic equilibria of nickel(II) with N,N'-di(aminoethylene)-2,6-pyridinedicarbonylamine (L1), Bis-(N,N-dimethylethyl)-2,6-pyridinedicarboxamide (L2), and N,N'-bis[2(2-pyridyl)-methyl]pyridine-2,6-dicarboxamide (L3) have been studied at 25 degrees C and an ionic strength of 0.15 mol dm(-3) by glass electrode potentiometry. The protonation and formation constants added to blood plasma model predict that Cu(II) competes effectively against Ni(II), Zn(II), and Ca(II) for these ligands in vivo.

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