Formation and antimicrobial activity of 2-azetidinones from selective ester cleavage in 1,3,3-trisubstituted 4-[2 '-(O-diarylacyl)hydroxyphenyl]-2-azetidinones

Journal article

Authors/Editors

Pheko, Tshepo

Research Areas

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Publication Details

Author list: Singh GS, Pheko T

Publisher: Publications & Information Directorate, Csir

Place: NEW DELHI

Publication year: 2008

Journal acronym: INDIAN J CHEM B

Volume number: 47

Issue number: 1

Start page: 159

End page: 162

Number of pages: 4

ISSN: 0376-4699

Languages: English-Great Britain (EN-GB)

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Abstract

Treatment of the 1,3,3-trisubstituted 4-[2'-(O-diarylacyl)-hydroxyphenoyl]-2-azetidinones with sodium hydroxide in ethanol at room temperature lead to selective cleavage of the ester linkage inl the substrates forming new 1,3,3-trisubstituted 4-(2'-hydroxyphenoyl)-2-azetidinones which have been characterized oil the basis of analytical and spectral (IR, H-1 and C-13 NMR, MS) data. The structure elucidation also involves application of the HMQC and HMBC Studies using 2-D NMR (H-1-C-13 COSY) spectra. The antibacterial and antifungal activities of the products are reported.

Keywords

antimicrobial activity, azetidinones, HMBC study, HMQC study

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