Synthesis, characterization of gold (III) complexes and an in vitro evaluation of their cytotoxic properties

Journal article

Authors/Editors

Muzenda, Edison

Research Areas

ENGINEERING AND TECHNOLOGY (Frascati classification)

Publication Details

Subtitle: Synthesis, characterization of gold (III) complexes and an in vitro evaluation of their cytotoxic properties

Author list:
Muzenda, Edison

Publisher: Society for Mining Metallurgy and Exploration

Publication year: 2014

Start page: 1

End page: 4

Number of pages: 4

ISSN: 0747-9182

URL: file:///C:/Users/kethmoloi/Downloads/PDF Document (7).pdf

Languages: English-United States (EN-US)

Abstract

Three tetradentate Schiff base ligands and gold (III) complexes have been synthesized by a 2:1 molar condensation of salicylaldehyde with ethylenediamine and o- phenylenediamine. The ligands are N,N'-bis (salicylaldehyde) ethylenediamine (1), N,N'-bis (salicylaldehyde) o- phenylenediamine (2) and N,N'-bis (salicylaldehyde)- dimethylbenzene-l,2-diamine. The prepared ligands and their complexes have been characterized by elemental analyses, melting points, infrared spectroscopy and 'H NMR. The spectral data of the ligands and their complexes are discussed in relation to structural changes due to complications. In vitro cytotoxic study results show that the gold complexes exhibit moderate activity and block the proliferation of WHCOl cells with an IC50 range of 19.02 - 45.27μM, and IC50 range of 10.03 - 68.54μM for the WHCO6 lines.

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