Abacavir alters the transcription of inflammatory cytokines in virologically suppressed, HIV-infected women.
Journal article
Authors / Editors
Research Areas
No matching items found.
Publication Details
Author list: MacLeod IJ, Rowley CF, Lockman S, Ogwu A, Moyo S, van Widenfelt E, Mmalane M, Makhema J, Essex M, Shapiro RL
Publication year: 2012
Journal: Journal of the International AIDS Society (1758-2652)
Journal acronym: J Int AIDS Soc
Volume number: 15
Issue number: 2
ISSN: 1758-2652
eISSN: 1758-2652
Languages: English-Great Britain (EN-GB)
Abstract
BACKGROUND\nMETHODS\nRESULTS\nCONCLUSIONS\nAbacavir (ABC) may be associated with a small, increased risk of myocardial infarction in HIV-infected adults, possibly related to cytokine-mediated inflammation.\nTo evaluate the induction of inflammatory cytokine transcription by ABC, we used samples from women randomized to receive zidovudine/lamivudine/ABC (Trizivir) or lopinavir/ritonavir and zidovudine/lamividine (Kaletra/Combivir) from the third trimester through six-months postpartum for the prevention of mother-to-child transmission (PMTCT). Women were matched by CD4 count and baseline HIV RNA. All women attained viral suppression (<50 copies/ml) by the time of sampling.\nFour cytokines showed a difference in expression between the treatment arms, all in a proinflammatory direction for the ABC arm: CD40LG 1.82-fold, (p=.027); IL-8 3.16-fold (p=.020); LTA 2.82-fold, (p=.008); and CCL5 -1.67-fold, (p=.035). At 12-months postpartum, 6-months after antiretroviral discontinuation, cytokine expression was similar by treatment arm.\nWe conclude that ABC may upregulate proinflammatory cytokines at the transcriptional level in this population.
Keywords
No matching items found.
Documents
No matching items found.
