Four-class drug-resistant HIV-1 subtype C in a treatment experienced individual on dolutegravir-based antiretroviral therapy in Botswana.
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Publication Details
Author list: Seatla KK, Avalos A, Moyo S, Mine M, Diphoko T, Mosepele M, Gaolatlhe T, Rowley CF, Ramaabya D, Jarvis JN, Kasvosve I, Gaseitsiwe S
Publisher: Lippincott, Williams & Wilkins
Publication year: 2018
Journal: AIDS (0269-9370)
Journal acronym: AIDS
Volume number: 32
Issue number: 13
Start page: 1899
End page: 1902
Number of pages: 4
ISSN: 0269-9370
eISSN: 1473-5571
Languages: English-Great Britain (EN-GB)
Abstract
: There are limited data on the effectiveness of dolutegravir (DTG)-based combination antiretroviral therapy (ART) in real-life settings in southern Africa where HIV-1 subtype C predominates. We report a patient infected with HIV-1 subtype C on DTG-based ART previously exposed to raltegravir who developed multidrug resistance mutations to four antiretroviral classes. There is need for drug resistance monitoring and clinical vigilance to ensure effectiveness of HIV treatment programs even in the era of DTG-based ART.
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