Infant feeding practices were not associated with breast milk HIV-1 RNA levels in a randomized clinical trial in Botswana.
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Author list: Rossenkhan R, Novitsky V, Sebunya TK, Leidner J, Hagan JE, Moyo S, Smeaton L, Lockman S, Musonda R, Ndung'u T, Gaseitsiwe S, Thior I, Mmalane M, Makhema J, Essex M, Shapiro R
Publisher: Springer (part of Springer Nature): Springer Open Choice Hybrid Journals
Publication year: 2012
Journal: AIDS and Behavior (1090-7165)
Journal acronym: AIDS Behav
Volume number: 16
Issue number: 5
Start page: 1260
End page: 4
Number of pages: -1255
ISSN: 1090-7165
eISSN: 1573-3254
Languages: English-Great Britain (EN-GB)
Abstract
Exclusive breastfeeding has been associated with a reduced risk of late vertical HIV transmission as compared to an infant diet composed of breast milk mixed with supplemental foods or liquids. Hypothesized mechanisms include increased infectivity of breast milk from mothers who practice mixed breastfeeding (MBF), or mechanisms such as increased gastrointestinal permeability in the infant caused by mixed feeding. It has been proposed that MBF may result in subclinical mastitis and higher breast milk HIV titers. However, little is known about the relationship between feeding strategy and breast milk viral load. We measured the HIV-1 concentration in breast milk in a sub-cohort of women enrolled in a mother-to-child HIV transmission prevention trial (the "Mashi" study). We report no observed relationship between MBF and measured breast milk viral RNA load. Our findings suggest that the increased transmission risk associated with higher breast milk HIV-1 RNA during MBF is unlikely.
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