Short Communication: Low False Recent Rate of Limiting Antigen-Avidity Assay Combined with HIV-1 RNA Data in Botswana.
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Author list: Moyo S, Kotokwe KP, Mohammed T, Boleo C, Mupfumi L, Chishala S, Tsalaile L, Bussmann H, Gaseitsiwe S, Musonda R, Makhema J, Baum M, Marlink R, Engelbrecht S, Essex M, Novitsky V
Publisher: Mary Ann Liebert
Publication year: 2017
Journal: AIDS Research and Human Retroviruses (0889-2229)
Journal acronym: AIDS Res Hum Retroviruses
Volume number: 33
Issue number: 1
Start page: 17
End page: 18
Number of pages: 2
ISSN: 0889-2229
eISSN: 1931-8405
Languages: English-Great Britain (EN-GB)
Abstract
Cross-sectional estimation of HIV incidence could misclassify some established or chronic HIV infections as recent. Usually long-term nonprogressors, elite and viremic controllers, and individuals on ART contribute to misclassification. Local data on the false recent rate (FRR) could minimize misclassification during estimation of HIV incidence. To improve monitoring of HIV incidence, we estimated local FRR in Botswana. A total of 1,036 specimens from individuals infected for at least 1.5-2 years were sampled between 2004 and 2009 and tested using the limiting antigen (LAg)-avidity assay using a cutoff of 1.5 normalized optical density units. The FRR was 0.97% (10/1,036; 95% confidence interval [CI] 0.46-1.77). Four samples had HIV-1 RNA >1,000 cps/ml, giving an adjusted FRR of 0.39% (4/1,036; 95% CI 0.11-0.99). A combination of LAg and HIV-1 RNA load data resulted in FRR below 1% in the Botswana population.
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