Comparison of plasma etonogestrel concentrations sampled from the contralateral-to-implant and ipsilateral-to-implant arms of contraceptive implant users.
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Author list: Gertz AM, Bishop IJ, Simon B, Lechiile K, Badubi O, Mussa A, Westhoff CL, Morroni C
Publisher: Elsevier: 12 months
Publication year: 2020
Journal: Contraception (0010-7824)
Journal acronym: Contraception
Volume number: 102
Issue number: 6
Start page: 403
End page: 405
Number of pages: 3
ISSN: 0010-7824
Languages: English-Great Britain (EN-GB)
Abstract
OBJECTIVE\nSTUDY DESIGN\nRESULTS\nCONCLUSIONS\nIMPLICATIONS\nTo compare plasma etonogestrel concentrations sampled from the contralateral- versus ipsilateral-to-implant arm.\nSub-analysis of a cross-sectional study in Botswana in 33 participants who provided contralateral and ipsilateral blood samples.\nPlasma etonogestrel concentrations in contralateral and ipsilateral specimens were highly correlated (correlation coefficient = 0.99; p < 0.0001). Bland-Altman analysis of agreement showed that etonogestrel levels were on average 5.9 pg/mL higher (2.1%) in ipsilateral compared to contralateral specimens (95% confidence interval: -4.1, 15.9 pg/mL).\nWe found no meaningful differences in plasma etonogestrel concentrations between samples taken from the contralateral- versus ipsilateral-to-implant arm.\nOur data suggest that etonogestrel plasma concentrations are unlikely to be meaningfully different between samples drawn from the ipsilateral- versus the contralateral-to-implant arms in etonogestrel contraceptive implant users.
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