Hypertensive disease in pregnancy in Botswana: Prevalence and impact on perinatal outcomes.
Journal article
Authors / Editors
Research Areas
No matching items found.
Publication Details
Author list: Johnson KM, Zash R, Haviland MJ, Hacker MR, Luckett R, Diseko M, Mayondi G, Shapiro R
Publisher: Elsevier
Publication year: 2016
Journal: Pregnancy Hypertension (2210-7789)
Journal acronym: Pregnancy Hypertens
Volume number: 6
Issue number: 4
Start page: 418
End page: 422
Number of pages: 5
ISSN: 2210-7789
Languages: English-Great Britain (EN-GB)
Abstract
OBJECTIVES\nSTUDY DESIGN\nMAIN OUTCOME MEASURES\nRESULTS\nCONCLUSIONS\nPerinatal morbidity in sub-Saharan Africa has been attributed to infection, obstetric emergencies, and preterm birth, but less is known about hypertension in pregnancy. Our objective was to characterize the prevalence of hypertension in pregnancy and the impact of hypertension on perinatal outcomes in sub-Saharan Africa.\nWe performed surveillance of obstetric records at eight of the largest public hospitals in Botswana. Women were included in this analysis if they were HIV-uninfected and had singleton gestations and at least one prenatal blood pressure measurement.\nWe measured stillbirth, preterm birth, small for gestational age, and neonatal death in women with and without hypertension in pregnancy.\nWe included 14,170 pregnancies. Hypertension occurred in 3156 (22.2%) women, with 602 (19.1%) defined as severe. Severe hypertension increased risk of stillbirth (RR 4.4; 95% CI 3.2-6.2), preterm birth (RR 2.5; 95% CI 2.2-2.8), small for gestational age (RR 2.7; 95% CI 2.3-3.1) and neonatal death (RR 5.1; 95% CI 2.9-5.6). Non-severe hypertension increased risk of stillbirth (RR 2.0; 95% CI 1.5-2.7), preterm birth (RR 1.2; 95% CI 1.1-1.3), and small for gestational age (RR 1.6; 95% CI 1.4-1.8). Perinatal outcomes were worse in women with hypertension who had spontaneous preterm birth compared to those who underwent iatrogenic preterm delivery.\nHypertension in pregnancy is common in Botswana and leads to a large number of adverse outcomes. Improved management of hypertension in pregnancy may improve perinatal morbidity and mortality.
Keywords
No matching items found.
Documents
No matching items found.
