HIV-Associated Cryptococcal Meningitis: Bridging the Gap Between Developed and Resource-Limited Settings.
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Author list: Tenforde MW, Wake R, Leeme T, Jarvis JN
Publication year: 0
Journal: Current Clinical Microbiology Reports (2196-5471)
Journal acronym: Curr Clin Microbiol Rep
Volume number: 3
Start page: 92
End page: 102
Number of pages: 11
ISSN: 2196-5471
Languages: English-Great Britain (EN-GB)
Abstract
Cryptococcal meningitis is a major cause of HIV-associated morbidity and mortality worldwide. Most cases occur in low-income countries, where over half of patients die within 10 weeks of diagnosis compared to as few as 10 % of patients from developed countries. A host of factors, spanning the HIV care continuum, are responsible for this gap in treatment outcomes between developed and resource-limited settings. We explore factors responsible for this outcomes gap and describe low-cost, highly effective measures that can be implemented immediately to improve outcomes in resource-limited settings. We also explore health-system challenges that must be addressed to reduce mortality further, recent research in disease prevention, and novel short-course treatment regimens that, if efficacious, could be implemented in resource-limited settings where the cost of standard treatment regimens is currently prohibitive.
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